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Growth Hormone

Growth hormone, also known as somatotropin, is a protein hormone of about 190 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary. It is a major participant in control of several complex physiologic processes, including growth and metabolism. Growth is a very complex process, and requires the coordinated action of several hormones. The major role of growth hormone in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-I. IGF-I stimulates proliferation of chondrocytes (cartilage cells), resulting in bone growth. Growth hormone does seem to have a direct effect on bone growth in stimulating differentiation of chondrocytes.

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The major role of growth hormone in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1 (insulin-like growth factor-1). IGF-1 stimulates both the differentiation and proliferation, or development, of myoblasts (muscle fiber). It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. IGF-1 is one of the most potent anabolic hormones in the body!

Growth hormone and IGF-1 have major roles in protein, fat and carbohydrate metabolism. This is metabolically significant to the athlete in that these hormones influence protein for growth, fatty acids and body fat reduction, and carbohydrates for energy and recovery.

• Growth hormone stimulates the anabolic amino acid uptake, increased protein synthesis and decreased oxidation of proteins. The more amino acids utilized by the cell and the greater the protein synthesis, the greater the muscle growth.

• Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes (fat cells).

• Growth hormone helps to maintain blood glucose within normal ranges. Growth hormone is said to have anti-insulin activity, because it suppresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver. Working in conjunction with the hormone- glucagon, growth hormone stimulates the release of fatty acids from storage for conversion to glucose. This action helps keep the body energized and the blood glucose stabilized during times when blood sugar levels drop. This important metabolic function supports fat to energy metabolism.

In humans the amount of growth hormone secreted at age 20 is about 500 micrograms, at age 40 200 micrograms, and at age 80 only 25 micrograms. The fall in IGF-1 is identical. GH and IGF-1 production can be increased significantly by the stimulation of growth hormone-releasing hormone (GH-RH) by the pituitary gland, and the suppression of somatostatin a feedback hormone that acts to block the release of GH.

• The body releases the highest levels of growth hormone during sleep and at times when blood glucose levels are low. Therefore secretagogue formulas can be consumed before sleep on an empty stomach to help facilitate the greatest potential for GH and IGF-1 synthesis and release.

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